منابع مشابه
Renal Interstitial Fibrosis and Angiotensin Inhibition
Tubulointerstitial (TI) fibrosis is a final common pathway to progressive renal injury of all forms of renal disease. However, once renal damage reaches a certain threshold, progression of renal disease is consistent, irreversible, and largely independent of the initial injury. Angiotensin (AT) II is the main effector of the renin angiotensin system (RAS) and effects that may contribute to the ...
متن کاملEndothelial Dysfunction in Renal Interstitial Fibrosis.
Kidney disease affects millions of people worldwide and it is now widely accepted that many pathological processes may persist after acute kidney injury that can cause the progression to CKD. Tubulointerstitial fibrosis manifests soon after injury and while many cellular and molecular components of kidney fibrosis have been discovered, largely in animal models, new therapeutic strategies are st...
متن کاملMathematical model of renal interstitial fibrosis.
Lupus nephritis (LN) is an autoimmune disease that occurs when autoantibodies complex with self-antigen and form immune complexes that accumulate in the glomeruli. These immune complexes initiate an inflammatory response resulting in glomerular injury. LN often concomitantly affects the tubulointerstitial compartment of the kidney, leading first to interstitial inflammation and subsequently to ...
متن کاملLPA1 receptor activation promotes renal interstitial fibrosis.
Tubulointerstitial fibrosis in chronic renal disease is strongly associated with progressive loss of renal function. We studied the potential involvement of lysophosphatidic acid (LPA), a growth factor-like phospholipid, and its receptors LPA(1-4) in the development of tubulointerstitial fibrosis (TIF). Renal fibrosis was induced in mice by unilateral ureteral obstruction (UUO) for up to 8 d, a...
متن کاملRenal interstitial fibrosis: remembrance of things past?
The decline in renal function seen in a variety of pathological states is associated with an increase in the number and changes in the protein synthetic activity of tubular interstitial cells. However, the relationship between expansion of the interstitial compartment (interstitial fibrosis) and loss of renal epithelial tubules and capillaries remains unclear. Interstitial pathologies accompany...
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ژورنال
عنوان ژورنال: Current Opinion in Nephrology and Hypertension
سال: 2012
ISSN: 1062-4821
DOI: 10.1097/mnh.0b013e3283521cfa